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Postdoctoral Position / Virus-Host Cell Interaction

     
Employer
University of Geneva Medical School
Department of Microbiology & Molecular Medicine
LocationGeneva, Switzerland
Discipline
Activity
Occupation rate100%
Duration12 months with possible extension of up to 3 years
Posted
Job startas soon as possible

Applications are invited for a Postdoctoral position to work on a newly discovered cellular antiviral defense mechanism. By studying the regulatory HBx protein of hepatitis B virus, we found that the Smc5/6 complex, which has important roles in chromosome maintenance, also functions as a host restriction factor against hepatitis B and possibly other pathogenic viruses. It binds to the hepatitis B virus circular DNA genome and more generally to any episomal DNA to block transcription and, thus, viral infection. Hepatitis B virus counters this host defense by encoding the HBx protein that targets the Smc5/6 complex for destruction. We now wish to explore how the Smc5/6 complex detects and binds selectively to episomal DNA templates and not to chromosomal DNA and how, once bound, it silences transcription.

Relevant references:
· Decorsière et al. (2016) Nature 531: 386 (also see Nature 531: 313)
· Van Breugel et al. (2012) Hepatology 56: 2116.
· Li et al. (2010) Nat Struct Mol Biol. 17: 105.

The appointment is initially for one year and may be renewed upon mutual satisfaction.

Requirements

Candidates should have at least one first author publication in press or published in a major international journal. Expertise in molecular and cellular biology would represent a major advantage.

Please note that only candidates currently residing in Europe will be considered for this position.

E-mail
Contact www.mimo.unige.ch...

Submission

Applications, including CV and contact details of two referees should be sent by email to:

Michel Strubin
Department of Microbiology & Molecular Medicine
C.M.U. / University of Geneva
E-mail: michel.strubinunige.ch
www.mimo.unige.ch/STRUBIN_LABb.htm

 
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