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Postdoctoral Position / Virus-Host Cell Interaction | |
Published | |
Workplace | Geneva, Rue Michel-Servet 1, Switzerland |
Category | |
Position | |
Duration | 12 months with possible extension of up to 3 years |
Occupation rate |
100% |
Job Start | as soon as possible |
Applications are invited for a Postdoctoral position to work on a newly discovered cellular antiviral defense mechanism. By studying the regulatory HBx protein of hepatitis B virus, we found that the Smc5/6 complex, which has important roles in chromosome maintenance, also functions as a host restriction factor against hepatitis B and possibly other pathogenic viruses. It binds to the hepatitis B virus circular DNA genome and more generally to any episomal DNA to block transcription and, thus, viral infection. Hepatitis B virus counters this host defense by encoding the HBx protein that targets the Smc5/6 complex for destruction. We now wish to explore how the Smc5/6 complex detects and binds selectively to episomal DNA templates and not to chromosomal DNA and how, once bound, it silences transcription. | |
Requirements Candidates should have at least one first author publication in press or published in a major international journal. Expertise in molecular and cellular biology would represent a major advantage. | |
Contact and Address Applications, including CV and contact details of two referees should be sent by email to: | |
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Web | |
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In your application, please refer to myScience.ch and reference JobID 39022. |